| 名稱(chēng) | TP53 p.G245C Reference Standard 標(biāo)準(zhǔn)品 |
| 型號(hào) | CBP10154 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | TP53 p.G245C Reference Standard |
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電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
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基因檢測(cè)標(biāo)準(zhǔn)品 > Mutation > CBP10154TP53 p.G245C Reference Standard 標(biāo)準(zhǔn)品
- 詳細(xì)內(nèi)容
CBP10154 | |
| Format | Genomic DNA |
| Description | TP53 G245C is a hotspot mutation that lies within the DNA binding domain of the Tp53 protein (PMID: 22713868). G245C results in a loss of transactivation of several targets of wild-type Tp53 (PMID: 22170099, PMID: 30126368), and also confers a gain-of-function to Tp53, as demonstrated through inhibition of Ampk activation in cell culture, and leads to increased tumor formation in mouse models (PMID: 24857548), and increased migration and invasion in culture (PMID: 30126368). |
| Technical Data | |
| DNA Change: | c.733G>T |
| AA Change | p.G245C |
| Mutation type | Substitution - Missense |
| Zygosity | Homozygous |
| Allelic Frequency | 100% |
| Transcript | ENST00000269305 |
| Cosmic ID | COSM11081 |
| Chr position(GRCh37) | chr17:7577548 |
| Buffer: | Tris-EDTA |
| Product Information | |
| Intended Use | Research Use Only |
| Unit Size | 1ug |
| Concentration | Download for COA |
| Purofication | Download for COA |
| DNA electrophoresis | Download for COA |
| Sanger sequencing | Download for COA |
| Storage | 4℃ |
| Expiry | 36 months from the date of manufacture |
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