| 名稱 | LAG3/CHO |
| 型號(hào) | CBP74052 |
| 報(bào)價(jià) |  |
| 特點(diǎn) | LAG3/CHO，凍存條件：90% FBS+10% DMSO； |
產(chǎn)品搜索
相關(guān)文章
- 人乳頭瘤病毒HPV核酸檢測(cè)標(biāo)準(zhǔn)品
- STING激動(dòng)劑和拮抗劑的篩選
- 【產(chǎn)品推介】腫瘤耐藥細(xì)胞株
- 腫瘤細(xì)胞的熱敏感特性分析
- 治療疼痛的潛力靶點(diǎn)——NGF
- PTPRZ1-MET腦膠質(zhì)瘤分子診斷標(biāo)準(zhǔn)品上新
- JCI：中山大學(xué)科學(xué)家找到可能*治愈常見白血病的新靶點(diǎn)
- 一箭雙雕——IL-4R靶點(diǎn)和IL-4/IL-13雙重阻斷藥篩細(xì)胞模型
- 優(yōu)生優(yōu)育配對(duì)標(biāo)準(zhǔn)品上新
- GABA細(xì)胞篩選模型
聯(lián)系我們
聯(lián)系人：蔣經(jīng)理
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
電話：4008750250
號(hào)碼：
手機(jī)：18066071954
地址：南京市棲霞區(qū)緯地路9號(hào)
Email： zhangxiangwen@cobioer.com
產(chǎn)品展示 / PRODUCTS
藥靶細(xì)胞株 > 腫瘤免疫細(xì)胞株 > CBP74052LAG3/CHO
- 詳細(xì)內(nèi)容
LAG3/CHO
| CBP74052 | |
| I. Background | |
| Lymphocyte-activation gene 3 (LAG3, CD223) is a cell surface protein that belongs to immunoglobulin (Ig) superfamily. LAG3 is expressed on activated T cells, natural killer cells, B cells, and plasmacytoid dendritic cells. Its main ligand is MHC class II, to which it binds with higher affinity than CD4. It negatively regulates cellular proliferation, activation, and homeostasis of T cells, in a similar fashion to CTLA-4 and PD-1, and has been reported to play a role in Treg suppressive function. A number of LAG3 antibodies are in preclinical development for treatments for cancer and autoimmune disorders. LAG3 may be a better immune checkpoint inhibitor target than CTLA-4 or PD-1 since antibodies to these two checkpoints are only activating effector T cells, and not inhibiting Treg activity where an antagonist LAG3 antibody can both activate effector T cells (by downregulating the LAG3 inhibiting signal) and inhibit induced (i.e. antigen-specific) Treg suppressive activity. | |
| II. Description | |
| Recombinant CHO cells constitutively expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286). | |
| III. Introduction | |
| Host Cell: | CHO |
| Expressed gene: | LAG3 |
| Stability: | 32 passages (in-house test, that not means the cell line will be instable beyond the passages we tested.) |
| Synonym(s): | LAG3, LAG-3, CD223 |
| Freeze Medium: | 90% FBS+10% DMSO |
| Culture Medium: | F12K+10%FBS+400ug/ml hygromycin |
| Mycoplasma Testing: | Negative |
| Storage: | Liquid nitrogen |
| Application(s): | Binding Assay,FACS |
| IV. Description of Host Cell Line | |
| Organism: | Cricetulus griseus, hamster, Chinese |
| Tissue: | Ovary |
| Disease: | Hamster Chinese ovary |
| Morphology: | Epitheloid cell |
| Growth Properties: | Adherent |
| Ⅴ. Representative Data | |
| |
Figure Recombinant CHO cells constitutively expressing human LAG3 (lymphocyte-activation gene 3, CD223, GenBank Accession # NM_002286). | |
會(huì)員_a.png)